South San Francisco, CA jobs, layoffs and employers
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Show me jobs near meJobs in South San Francisco
- Senior Drug Discovery ScientistAxiom Bio
- Warehouse ManagerShort Story
- Computational Scientist (Biology)Axiom Bio
- Bilingual HR & Recruiting CoordinatorShort Story
- Executive Advisory Programs ManagerStripe
- Credit Risk, Fraud StrategistStripe
- Senior/Executive Medical Director, Clinical Development (New Indications)Alumis
- Principal Software EngineerNatera
- Scientist R&DNatera
- Executive Director, Clinical Regulatory - Rare DiseasesDenali Therapeutics
Employers hiring most in South San Francisco
- Newlimit13 open roles
- IDEAYA Biosciences11 open roles
- Gritt Robotics9 open roles
- Denali Therapeutics8 open roles
- Marea Therapeutics5 open roles
- Blue Matter Consulting4 open roles
- Ohalo Genetics4 open roles
- Andromeda Surgical3 open roles
- Axiom Bio3 open roles
- Stripe3 open roles
South San Francisco layoffs
4
Layoff notices, last 12 months
262
workers named
A floor: states may leave out counts
4
employers
| Notice date | Employer | City or county | Workers | Type | Source |
|---|---|---|---|---|---|
| Arsenal Biosciences, Inc.Takes effect Oct 29, 2026 | San Mateo County | 58 | Layoff Permanent | State record | |
| Cellares CorporationTakes effect Oct 20, 2026 | San Mateo County | 100 | Layoff Permanent | State record | |
| Yerba Mate Co., LLC - South San FranciscoTakes effect Sep 1, 2026 | San Mateo County | 1 | Layoff Permanent | State record | |
| Genentech, Inc.Takes effect Jul 29, 2026 | San Mateo County | 103 | Layoff Permanent | State record |
Conferences in South San Francisco
Industry conferences and trade shows held in South San Francisco. 1 with dates announced.
- HRWest
Mar 23 to Mar 24, 2027 · South San Francisco, CA
Ticket $399 to $999. Early-bird $399 through Jan 15 2027; $799 regular; $999 onsite.
Open call for speakers · deadline Oct 30, 2026
San Mateo County outlook: Cooling
Built from public Bureau of Labor Statistics and Census figures. It describes the area, not any one employer in it.
- Private-sector jobs down 3.0% from 2022 to 2025
- Population down 2.5% from 2020 to 2025
- Unemployment 3.9%, down 0.2 points from a year ago
- Sectors adding the most jobs: health care (+6,866 jobs), hotels & food (+3,546 jobs)
- Sectors losing the most jobs: information (−18,948 jobs), manufacturing (−4,940 jobs)
Local job-market news
Recent headlines about layoffs, AI and jobs in South San Francisco. Each link goes to the publisher.
- Aria Networks plans to triple workforce with Sunnyvale moveThe Business Journals · Oct 16, 2026
Learn and get funded in South San Francisco
- Which AI skills each kind of job asks for, with the pay premium.
- Your local workforce board and American Job Centers: training vouchers and re-employment help.
- Grants and funding for job seekers, ranked for your state and situation.
- Unemployment benefits by state, if you are between jobs.
Workforce development and job centers
The public workforce board and American Job Centers serving South San Francisco. They offer free help with job search, training and filing for benefits.
Laid off in California? How to file for unemployment in California (steps, weekly amount and the appeal deadline).
- NOVA Workforce Development Board
San Mateo; Cities: Cupertino, Milpitas, Mountain View, Palo Alto, Santa Clara, Sunnyvale
San Mateo County economy
3.9%
unemployment, Sep 2026
4.1% the month before
410,701
in the labor force
Source: BLS Local Area Unemployment Statistics
745,100
people in San Mateo County
Source: U.S. Census Bureau
$156,000
median household income
Source: Census ACS
55%
of workers in white-collar occupations
Management, business, financial and professional; Census ACS
More cities in San Mateo County
Laid off or looking for work in South San Francisco?
See what to do first and the jobs open near you.
See your options after a layoffSources: Layoff notices from California’s published record; job counts from our live job board, taken from employers’ own career sites; IPEDS for colleges; CareerOneStop for workforce boards and job centers; Census Bureau and BLS for county figures. California unemployment benefits and severance rules.
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