Systems Administrator III
Edgewise Therapeutics
Boulder, CO · Posted September 9, 2026
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About the job
At Edgewise, we are focused on advancing novel, muscle-targeted therapeutics for serious cardiovascular and cardiometabolic conditions with significant unmet need. Leveraging our expertise in muscle biology and small molecule drug development, we are building a cardiovascular pipeline that includes programs for hypertrophic cardiomyopathy, heart failure and other serious cardiovascular diseases.
We’re building a passionate, experienced team committed to tackling complex scientific and clinical challenges and delivering meaningful outcomes for patients. If you’re looking to do work that matters, we’d love to hear from you.
About the Position:
The Systems Administrator III will support Edgewise’s IT systems, applications, and end-user technology needs. This role provides advanced technical support, administers key cloud-based platforms, supports onboarding and offboarding, and helps maintain IT operations across business, lab, and hybrid work environments. The ideal candidate is customer-focused, technically strong, and proactive in improving systems and support processes.
Essential Job Duties and Functions:
Provide consistent assistance and support for tier I and II level IT technicians in resolving technical issues.
Ensure comprehensive documentation of technical issue resolutions and updates for support tickets.
Administer various cloud-based systems, overseeing user activity monitoring, policy creation, and troubleshooting.
Utilize advanced content search skills for data discovery and retrieval, supporting legal inquiries across multiple platforms.
Work with internal IT support teams to build and update approved third-party software packages for user and lab systems.
Perform routine maintenance and troubleshooting on computers and IT systems.
Act as a point of contact for all computer and system-related concerns of Edgewise users.
Respond to customer inquiries promptly and accurately.
Administer and manage the following applications and processes as required by leadership:
Microsoft 365 complete product suite including focus on Intune, Entra (including single sign on) and Defender.
Box – GXP and non GXP administration and management.
Zendesk ticketing system - Create and maintain workflows for automated ticket routing to support teams.
Adobe - Maintain and manage user accounts and product licenses.
Docusign CFR Part 11 and regular - Manages user accounts and access.
Zoom – Administration and management
Coupa – Administration and management. SOX experience preferred
Netsuite - Administration and management. SOX experience preferred
Veeva Basics – Administration
SmartSheet - Administration and management
Conducts IT orientation and onboarding for all new hires.
Support for IT Offboarding process for all departing employees, contractors, and service providers.
Works closely with HR and InfoSec to ensure all user access is disabled and data retention procedures are completed accordingly.
Support for on premise networking, Audiovisual and wireless solutions.
Experience of ELN, Visualization tools, Systems Validation preferred
Required Education, Experience and Skills:
Bachelor’s degree in computer science or equivalent IT certifications with 5+ years of previous Service Desk experience for a mid-size company.
Certifications in any of the above applications preferred.
Excellent technical knowledge of desktop and software, including all Windows 11 Enterprise, Microsoft Office 365, and Lenovo hardware.
Relevant work experience including but not limited to hands-on hardware troubleshooting experience; applications support including knowledge of IT support systems.
Strong customer service skills, including ability to listen, interpret, and explain IT related concepts in non-technical terms.
Experience in hybrid/remote cloud-based Lifesciences organizations required - Comfortable working in a lab environment.
Independent thinker, proactive in improving IT systems.
Strong team orientation with ability to work outside of assigned duties.
Ability to prioritize and manage several milestones and projects efficiently.
Multiple computer-related qualifications and certifications will be viewed favorably.
Travel may be required (not expected more than 10%)
Subject to extended periods of sitting and standing, vision to monitor, and moderate noise level.
Salary range: $85,000-$125,000, title and salary commensurate with experience
Our Benefits: We are proud to offer health benefits, a discretionary bonus plan, stock option grants. a stock purchase plan, a 401(k) with match and paid time off to our team members as part of their compensation plan.
There is no deadline because the employer accepts applications on an ongoing basis.
Edgewise does not accept resumes from recruitment agencies for this position. Please do not send resumes to Edgewise employees or the company location. Edgewise is not responsible for any fees related to unsolicited resumes.