Senior Research Associate, Biophysics, Mechanism of Action

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

The Opportunity:

As a key member of our dynamic Mechanism of Action team within Discovery Biology under the Biomedical Discovery Research (BDR) department, you will have responsibilities including, but not limited to:

• Perform label-free biophysical assays (BLI, SPR) to inform the mode of action of small molecule and tri-complex inhibitors.

• Assist in the development and troubleshooting of SPR methods for novel applications.

• Assist in the transfer of established methods for routine screening.

• Perform data analysis, prepare experimental result reports, upload data to electronic notebooks, and present findings to project teams.

• Support laboratory operations, including lab safety, instrument maintenance, and ordering of essential consumables.

Required Skills, Experience and Education:

• BSc or MS in biological sciences or a related scientific discipline, with 5+ years of industry experience for BSc holders or 3+ years for MSc holders.

• Hands-on experience in operating and maintaining SPR (Cytiva Biacore or Carterra LSA) and BLI (Octet or Gator) systems.

• Hands-on experience in SPR/BLI method development and data analysis.

• Hands-on experience in working diverse sample types (cell lysates, purified proteins, clarified supernatant).

• Ability to customize and follow established assay protocols.

• Ability to manage multiple laboratory and project tasks efficiently.

• Ability to work effectively in a flexible, team-oriented environment.

• Highly organized and detail-oriented, with excellent recordkeeping skills and the ability to adapt to a dynamic, fast-paced environment.

Preferred Skills:

• Experience performing label-free biophysical assays with biologics.

• Prior experience with epitope binning, titer determination, off-rate ranking.

• Previous hands-on experience with TR-FRET assay development.

• Prior experience with biophysical techniques such as DLS, DSF, and SEC.

• Prior experience with automated liquid handling systems (Opentrons, Hamiliton STAR, DragonFly, Tecan systems).

#LI-SB1 #LI-Onsite

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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Base Pay Salary Range

$106,000—$126,000 USD

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