E11 Bio - Scientist I/II, Expansion Microscopy

E11 Bio is on a mission to advance connectomics towards the scale of whole mammalian brains. We are a collaborative and interdisciplinary team of scientists and engineers engaged in a neuroscience moonshot project to develop a radical technology platform for scalable brain mapping. E11 Bio is a non-profit Convergent Research focused research organization located in Alameda, California, pursuing blue-skies neuroscience research yet operating like a nimble, tight-knit start-up. Read our technology roadmap.

We are seeking a mission-aligned scientist or engineer who is equally comfortable at the bench, the microscope, and with quantitative data analysis. This role combines sample preparation, advanced microscopy, quantitative image analysis, with engineering-driven technology development focused on quick iterative troubleshooting and standardizing and automating protocols. You will collaborate closely with molecular biology, imaging, and computational teams to ensure we consistently prepare high quality specimens to support our ambitious scaling goals towards whole-brain connectomics.

The role forms a critical part of our sample production pipeline and will be responsible for expansion microscopy development and iteratively improving protocols. Your work will drive two overarching outcomes: improving gel performance and improving the quality, reproducibility and scalability of sample production. This combines hands-on experimental work with defining quantitative metrics to assess mechanical and optical gel properties, image quality and pipeline throughput.