Senior Director - AI
Mayo Clinic
Rochester, MN · Posted October 27, 2026
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Where Rochester, MN ranks
Where Rochester, MN placed in our monthly rankings, month by month. Each month stays online at its own address.
November 2026
- #5Cities with the most hybrid jobs in the Great Lakes19% · of 50
- #7Cities with the most hybrid jobs in the Midwest19% · of 67
- #8Best cities for AI-skill jobs in the Midwest10% · of 69
- #8Best cities for AI-skill jobs in the Great Lakes10% · of 53
- #10Best cities for entry-level jobs that want AI skills in the Great Lakes4% · of 38
- #12Best cities for entry-level jobs that want AI skills in the Midwest4% · of 52
Rankings about data & analytics jobs
- Best cities for data and analytics jobs #1 New York (1,713 openings)
- Best cities for data and analytics pay after cost of living #1 Foster ($232k)
- Most requested AI skills in data and analytics jobs #1 Machine learning engineering (17.1%)
- AI tools named most often in data and analytics jobs #1 Databricks (7.6%)
- Employers with the most data and analytics jobs #1 Amazon (711 roles)
Data & Analytics jobs · Top Data & Analytics employers · All rankings
How AI is used in this kind of work
Among computer and information research scientists, AI is already used for a large share of the tasks. Measured exposure for computer and information research scientists: 34% (high).
Share of this job’s tasks that AI is already used for at work, from real usage. It is not a forecast of job loss, and a low number means no use seen yet. Source: Anthropic Economic Index.
About the job
The Senior Director, AI leads the engineering and research team that builds and delivers Mayo Clinic DigPath's digital-biology technology platforms, accountable for translating the organization's vision into validated, deployed products. Working closely with the Vice President, Digital Biology, the Chief Medical Officer, and the Chief Science Officer, the Senior Director helps shape technical direction and owns its execution—the roadmap, delivery, and technical quality for DigPath's core model and platform portfolio, including foundation and task-specific models, AI Virtual Cells, biological digital twins, and digital biomarker discovery. Directing a multidisciplinary team of AI/ML engineers, software developers, and research scientists, the Senior Director turns clinical and scientific priorities into engineering execution - partnering with the CMO for clinical relevance and the CSO for scientific rigor - to consistently ship breakthrough tools with speed, technical excellence, and unwavering focus on Mayo Clinic's core value: the needs of the patient come first.
The leader's primary responsibility will be managing highly matrixed cross-functional activities and personnel, with oversite for departmental AI governance, technology, and operations. The leader will also work alongside Chairs representing the department across Mayo Clinic, partnering closely with Shield leaders, and coordinating with other enterprise and Site leaders and governance bodies.
This vacancy is not eligible for sponsorship/ we will not sponsor or transfer visas for this position. Also, Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program.
Bachelor’s degree in a relevant field, such as Business Administration, Computer Science, AI/ML Engineering, Software Engineering, Information Systems, Design, or Health Informatics plus 10 years of related experience, including executive-level management of digital, technology, security, or product teams in complex organizations.
Master's degree in Business, Law, Computer Science, Engineering, Design, Healthcare Administration, or a related field preferred. Experience in integrated healthcare, academic medical centers, or regulated industries preferred.
Why Mayo Clinic
Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.
Benefits Highlights
Medical: Multiple plan options.
Dental: Delta Dental or reimbursement account for flexible coverage.
Vision: Affordable plan with national network.
Pre-Tax Savings: HSA and FSAs for eligible expenses.
Retirement: Competitive retirement package to secure your future.