Principal Machine Learning Engineer
Genentech
New York, NY · $193k–$358k a year · Posted November 6, 2026
Just laid off? Start here: a plan for the first weeks
See every open role at Genentech
More in New York job market · All Principal Machine Learning Engineer jobs (75) · Pharmaceuticals & Biotech · Data & Analytics jobs
Similar jobs
- Senior Data Platform Engineer · Thomson Reuters · New York, NY
- AVP, Backend Software Engineer - AWS / Cloud Native · Mid Oregon Credit Union · NY
- Senior IT Engineer – CONTRACTOR · ING Financial Services · New York, NY
- Staff Machine Learning Engineer · Estee Lauder Companies · New York, NY
- DevSecOps Platform Engineer · Ralliant · Rochester, NY
- Associate, Systems Engineer · L3HARRIS Technologies · Canoga Park, CA
Where New York, NY ranks
Where New York, NY placed in our monthly rankings, month by month. Each month stays online at its own address.
November 2026
- #1Best cities for operations jobs1,429 openings · of 100
- #1Best cities for sales jobs2,774 openings · of 78
- #1Best cities for finance jobs1,932 openings · of 78
- #1Best cities for data and analytics jobs1,713 openings · of 58
- #1Best cities for HR jobs994 openings · of 30
- #1Best cities for marketing jobs1,754 openings · of 31
Rankings about data & analytics jobs
- Best cities for data and analytics jobs #1 New York (1,713 openings)
- Best cities for data and analytics pay after cost of living #1 Foster ($232k)
- Most requested AI skills in data and analytics jobs #1 Machine learning engineering (17.1%)
- AI tools named most often in data and analytics jobs #1 Databricks (7.6%)
- Employers with the most data and analytics jobs #1 Amazon (711 roles)
Data & Analytics jobs · Top Data & Analytics employers · All rankings
Pay compared with the market
This listing pays about $275,000 a year. Across 36 open principal machine learning engineer listings that state pay, the middle half runs $212,500 to $315,000 and the median is $265,500. That is inside the middle half of those listings, 4% above the median.
Listed pay is what employers advertise, not what people are paid.
Principal Machine Learning Engineer salaries by state · Check your own pay
How AI is used in this kind of work
Among computer occupations, all other, AI is already used for a large share of the tasks. Measured exposure for computer occupations, all other: 31% (high).
Share of this job’s tasks that AI is already used for at work, from real usage. It is not a forecast of job loss, and a low number means no use seen yet. Source: Anthropic Economic Index.
Genentech has filed one layoff notice in the last twelve months, covering 103 workers, most recently June 2026. These are public filings with state labor departments, and an open role can sit alongside them. See the filings
Skills this job asks for
Say which you have and which you want to build. We use it to match you to jobs like this one.
About the job
...Discovery (AIDD) group (Prescient Design), we are revolutionizing drug discovery with cutting-edge machine learning. We are seeking a Principal Machine Learning Engineer to join our Foundation Models team. In this role, you will drive the engineering, scaling, and operationalization...