Principal Plant Engineer - HVAC, CVRM
Genentech
Holly Springs, NC · $95k–$177k a year · Posted November 2, 2026
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Engineering jobs in the rankings
Rankings about engineering jobs
- Best cities for software and engineering jobs #1 San Francisco (3,412 openings)
- Best cities for engineering pay after cost of living #1 San Mateo ($216k)
- Most requested AI skills in engineering jobs #1 AI tools in daily work (6.1%)
- AI tools named most often in engineering jobs #1 Claude (1.7%)
- Employers with the most engineering jobs #1 Amazon (2,992 roles)
How AI is used in this kind of work
AI use among industrial engineers is little observed so far. Measured exposure for industrial engineers: 4% (little observed).
Share of this job’s tasks that AI is already used for at work, from real usage. It is not a forecast of job loss, and a low number means no use seen yet. Source: Anthropic Economic Index.
Genentech has filed one layoff notice in the last twelve months, covering 103 workers, most recently June 2026. These are public filings with state labor departments, and an open role can sit alongside them. See the filings
About the job
...plant—you will build the future of medicine. The Opportunity We're seeking a highly skilled and experienced Principal Plant Engineer who will be the site’s highest-level technical subject matter expert (SM) for the site’s HVAC/R program, including end-to-end asset...