Senior / Staff Software Engineer
Autoscience Institute
San Mateo, CA · Posted March 11, 2026
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Where San Mateo, CA ranks
Where San Mateo, CA placed in our monthly rankings, month by month. Each month stays online at its own address.
November 2026
- #1Best cities for engineering pay after cost of living$216k · of 94
- #1Best cities for finance pay after cost of living$162k · of 35
- #1Best cities for HR pay after cost of living$158k · of 15
- #1Best cities for legal pay after cost of living$238k · of 20
- #1Best cities for security pay after cost of living$241k · of 10
- #1Best cities for media and entertainment pay after cost of living$209k · of 9
Rankings about engineering jobs
- Best cities for software and engineering jobs #1 San Francisco (3,412 openings)
- Best cities for engineering pay after cost of living #1 San Mateo ($216k)
- Most requested AI skills in engineering jobs #1 AI tools in daily work (6.1%)
- AI tools named most often in engineering jobs #1 Claude (1.7%)
- Employers with the most engineering jobs #1 Amazon (2,992 roles)
Pay compared with the market
This listing does not state pay. Across 179 open senior listings that state pay, the middle half runs $176,000 to $256,500 and the median is $215,000.
Listed pay is what employers advertise, not what people are paid.
How AI is used in this kind of work
Among software developers, AI is already used for some of the tasks. Measured exposure for software developers: 29% (some).
Share of this job’s tasks that AI is already used for at work, from real usage. It is not a forecast of job loss, and a low number means no use seen yet. Source: Anthropic Economic Index.
Skills this job asks for
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About the job
Company Description
At Autoscience Institute, we automate AI research. Recently, we announced the first AI agent to autonomously create peer-reviewed literature (ICLR 2025) and the first AI system to win a Kaggle medal. We are passionate about pushing the boundaries of artificial intelligence and contributing to groundbreaking advancements in the field.
Role Description
This is a full-time on-site role for a Senior or Staff Software Engineer (Technical Lead) located in the San Francisco Bay Area.
In this role, you will lead the design and development of core systems that power autonomous research agents. You’ll be responsible for building reliable backend infrastructure and production systems that support large-scale AI experimentation and research workflows.
We are looking for engineers who have owned complex projects end-to-end, contributed to system architecture, and helped guide small teams of engineers through delivery. You should be comfortable writing high-quality code, producing clear design documents, and making thoughtful technical decisions that shape how systems evolve over time.
You will work closely with both engineers and researchers to translate experimental ideas into robust production systems.
Responsibilities
- Lead the design and implementation of core backend and infrastructure systems
- Own projects from architecture and design through production deployment
- Write clear technical design documents and drive engineering decisions
- Build and maintain 24/7 production systems supporting autonomous research agents
- Partner closely with research teams to productionize experimental workflows
- Guide and collaborate with engineers on system design and implementation
- Improve system reliability, scalability, and observability
- Help shape the technical direction of the platform
Qualifications
- Experience leading complex engineering projects or technical initiatives
- Experience acting as a technical lead or guiding small teams of engineers
- Strong software design and architecture skills
- Demonstrable experience writing clear technical design documents
- Strong experience with Python
- Experience building or operating backend or production infrastructure
- Experience working in 24/7 production environments
- Experience with Google Cloud Platform (GCP) or similar cloud infrastructure
- Strong understanding of software evolution, maintainability, and system design tradeoffs
- Ability to collaborate effectively with both engineers and researchers
- Bachelor’s degree in Computer Science, Mathematics, or a related field
- Strong candidates will typically have 5+ years of experience building and operating production software systems, including ownership of projects from design through deployment
Benefits & Perks
- Our comp is competitive against major LLM frontier lab packages
- Unlimited PTO and flexible working arrangements
- Conference attendance and publication support
Our Culture
We're a team of passionate researchers and engineers working to automate scientific discovery. We believe in the power of AI to accelerate scientific discovery and are committed to responsible AI development.