← Search all jobs

Software Engineer, Compute Infrastructure

Chai Discovery

San Francisco, CA · Posted November 25, 2025

Just laid off? Start here: a plan for the first weeks

See every open role at Chai Discovery

More in California job market · All Software Engineer jobs (1,994) · Technology & Software · Engineering jobs

More roles at Chai Discovery

Similar jobs

Where San Francisco, CA ranks

Where San Francisco, CA placed in our monthly rankings, month by month. Each month stays online at its own address.

Pay compared with the market

This listing does not state pay. Across 696 open software engineer listings that state pay, the middle half runs $168,000 to $251,000 and the median is $201,500.

Listed pay is what employers advertise, not what people are paid.

Software Engineer salaries by state · Check your own pay

How AI is used in this kind of work

Among software developers, AI is already used for some of the tasks. Measured exposure for software developers: 29% (some).

Share of this job’s tasks that AI is already used for at work, from real usage. It is not a forecast of job loss, and a low number means no use seen yet. Source: Anthropic Economic Index.

Check how this applies to your own job

About the job

ABOUT CHAI DISCOVERY

Chai Discovery builds the computer-aided design suite for molecules. Eli Lilly https://endpoints.news/eli-lilly-chai-discovery-sign-ai-software-deal/, GSK https://endpoints.news/chai-discovery-signs-gsk-deal-to-make-biologics-with-ai/, Pfizer https://www.forbes.com/sites/amyfeldman/2026/06/04/why-pfizer-and-eli-lilly-are-betting-on-this-13-billion-ai-drug-discovery-startup/, Bristol Myers Squibb https://www.linkedin.com/feed/update/urn:li:activity:7496300911523246080/, argenx https://x.com/chaidiscovery/status/2077422480617267230?s=20 and Novartis https://www.chaidiscovery.com/news/novartis-partnership all use Chai to power drug discovery programs. AI is reinventing life sciences the same way it reinvented software engineering, and our team is building that future.

We train frontier models that learn the underlying foundations of biochemical structure and interaction. We pair this with a computational workspace to iterate on molecules from idea to medicine, helping scientists move faster and develop medicines beyond the reach of existing methods.

We value diverse perspectives and are ready to find greatness in unexpected places.

ABOUT THE ROLE

Build the compute infrastructure behind Chai’s next generation of models, scientific products, and autonomous research. Our research program and runtime inference constantly demand more compute, and the rate at which we bring it online and manage it effectively directly inflects Chai's velocity.

- Bring new clusters up and own the systems that make them useful across the business.

- Work with researchers, engineers, and scientists to remove performance and reliability bottlenecks across the stack.

- Optimize model inference and serving to run more scientific work with available compute.

- Build the shared storage and security foundations that let people and agents use compute and data safely.

ABOUT YOU

We look for depth in distributed systems, compute infrastructure, and performance engineering, with demonstrated ownership of substantial production systems. You can reason across layers and make sound tradeoffs between complexity, reliability, and efficiency.

WE OFFER

The opportunity to work at the vanguard of AI research and frontier biology, with world-class people, on a mission that matters. We protect and promote a culture of high velocity and ownership. We compensate our team accordingly.