Senior AI/ML Engineer (Hybrid)
Mayo Clinic
Rochester, MN · Posted August 17, 2026
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Where Rochester, MN ranks
Where Rochester, MN placed in our monthly rankings, month by month. Each month stays online at its own address.
November 2026
- #5Cities with the most hybrid jobs in the Great Lakes19% · of 50
- #7Cities with the most hybrid jobs in the Midwest19% · of 67
- #8Best cities for AI-skill jobs in the Midwest10% · of 69
- #8Best cities for AI-skill jobs in the Great Lakes10% · of 53
- #10Best cities for entry-level jobs that want AI skills in the Great Lakes4% · of 38
- #12Best cities for entry-level jobs that want AI skills in the Midwest4% · of 52
Rankings about data & analytics jobs
- Best cities for data and analytics jobs #1 New York (1,713 openings)
- Best cities for data and analytics pay after cost of living #1 Foster ($232k)
- Most requested AI skills in data and analytics jobs #1 Machine learning engineering (17.1%)
- AI tools named most often in data and analytics jobs #1 Databricks (7.6%)
- Employers with the most data and analytics jobs #1 Amazon (711 roles)
Data & Analytics jobs · Top Data & Analytics employers · All rankings
How AI is used in this kind of work
Among computer and information research scientists, AI is already used for a large share of the tasks. Measured exposure for computer and information research scientists: 34% (high).
Share of this job’s tasks that AI is already used for at work, from real usage. It is not a forecast of job loss, and a low number means no use seen yet. Source: Anthropic Economic Index.
Skills this job asks for
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About the job
AI/ML Engineers at Mayo Clinic play a pivotal role in the union of data, systems, and computer sciences. They work closely with a multidisciplinary team, including clinicians, user experience designers, product managers, IT professionals, and external partners, to develop and deploy effective, efficient, and ethical AI/ML solutions into clinical practice to enhance patient care and operational efficiency.
As a Senior AI/ML Engineer, you may work on the full spectrum of the AI life cycle from ideation to production. You understand the clinical environment well, including workflows, challenges, and requirements of healthcare providers and patients. You will leverage advanced techniques in AI/ML to analyze vast amounts of healthcare data, including patient records, medical imaging, and genomic information, to develop AI solutions that meet clinical needs and are integrated smoothly into clinical processes. You will develop, integrate, and standardize software components and create, maintain, and follow quality system procedures. You will guide the engineering of systems that are pivotal to developing and deploying these solutions, which encompass everything from design requirements, development, component creation, verification, non-clinical validation, and risk mitigation to ensure our digital health technology products meet and exceed regulatory requirements and setting new benchmarks for safety and effectiveness in clinical settings. Your expertise will also extend to facilitating consistent and automated AI software solution development and releases through the design, testing, and maintenance of tools and associated CI/CD pipelines. This role is instrumental in providing consultative services to departments and divisions, offering insights into complex business problems. Your ability to communicate complex findings in easily understandable terms to non-technical users will bridge the gap between sophisticated AI technologies and clinical applications.
• Leading component design, development, integration, and standardization to create AI-driven solutions that seamlessly integrate into clinical practice to enhance patient care and clinic operations. • Collaborating with a multidisciplinary team, including clinicians, user experience designers, product managers, and IT professionals, to understand user needs, workflows, and clinical requirements and assess feasibility. Translating user feedback and requirements into design concepts and usability specifications for AI solutions. • Leveraging machine learning techniques such as deep learning, natural language processing, computer vision, large language models, etc., to lead the design, development, and deployment of end-to-end AI solutions for healthcare applications. • Establishing evaluation methodologies and performance metrics to assess AI solutions' effectiveness, usability, and impact in real-world healthcare settings. • Explaining data analysis results to guide strategic choices and clarify complex insights for non-technical users to connect AI technologies and clinical applications. • Overseeing the engineering of systems crucial for developing and deploying AI solutions. • Facilitating consistent and automated AI software solution development and releases through the design, testing, and maintenance of tools and associated CI/CD pipelines. • Contributing to implementing the best practices and standards for AI development and deployment methodologies, tools, and platforms. • Providing mentorship, guidance, and technical leadership to junior engineers within the AI enablement team. • Providing consultative services on areas of expertise to clinical work units or AI product teams, offering insights and strategies to address complex business problems. • Providing training and education to healthcare staff on AI tools and technologies. • Contributing to developing new AI methods and technologies that can advance the state-of-the-art in healthcare AI.
This vacancy is not eligible for sponsorship/ we will not sponsor or transfer visas for this position. Also, Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program.
• A master’s degree in engineering, computer science, mathematics, health science, or a related field with 4 years of experience, a bachelor’s degree with 6 years of experience. • Extensive experience applying AI and machine learning in production healthcare environments or similar highly regulated or technology focused industries, showcasing an understanding of healthcare technology. • Demonstrated leadership in managing complex projects, with a proven ability to navigate intricate project requirements and deliver successful outcomes. • Proficiency in fostering collaboration across diverse teams and effectively communicating complex technical concepts to non-technical stakeholders. • Demonstrated expertise in cloud infrastructure environment and software development tools. • Experience working with large, complex, and heterogeneous data sets, preferably in healthcare. • Skilled in AI/ML techniques and frameworks. • Familiarity with best practices in data engineering, data science, AI Engineering, and the MLOps communities. • Demonstrated initiative in administration, education, software development, and technical reporting. • A commitment to mentoring and training less-experienced team members, coupled with strong interpersonal, communication, and time management skills.
Preferred Qualifications: • A Ph.D. or other doctorate is preferred. • Strong expertise in AI/ML techniques and frameworks, such as deep learning, natural language processing, and Generative AI, with proficiency in tools like Python, TensorFlow, PyTorch, sci-kit-learn, Keras, etc. • Knowledge of the healthcare domain, including clinical workflows, electronic health records, medical terminologies, regulatory requirements, and industry standards. • Familiarity with systems or quality engineering best practices, regulatory standards, and compliance frameworks, with the ability to adapt these effectively to different project scenarios. • Demonstrated experience leading technical/quantitative teams in a regulated environment. • Demonstrated experience creating risk management files and verification/validation strategies for digital health technology products within the healthcare industry. • Strong expertise in user-centered design, human factors engineering, usability testing methodologies, and evaluation across AI product development. Ability to conduct expert reviews using established usability practices and methods. Presents findings in easy-to-understand terms for the business or clinical practice.
Why Mayo Clinic
Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.
Benefits Highlights
Medical: Multiple plan options.
Dental: Delta Dental or reimbursement account for flexible coverage.
Vision: Affordable plan with national network.
Pre-Tax Savings: HSA and FSAs for eligible expenses.
Retirement: Competitive retirement package to secure your future.