Principal Software Applications Engineer Onsite in Burlington MA
GLAUKOS
Burlington, MA · Posted July 22, 2026
Just laid off? Start here: a plan for the first weeks
See every open role at GLAUKOS
More in Massachusetts job market · Pharmaceuticals & Biotech · Engineering jobs
More roles at GLAUKOS
- Manager/Sr. Manager, Labeling Compliance · Aliso Viejo, CA
- Quality Engineer II · San Clemente, CA
- Business Systems Manager-Quality · Aliso Viejo, CA
- Manufacturing Engineer II · San Clemente, CA
- Clinical Lead/Project Manager Onsite or Remote
- Sr. Scientist, Drug Delivery · Aliso Viejo, CA
Similar jobs
- Software Architect · Massachusetts Institute of Technology (Lincoln Lab) · Lexington, MA
- Principal Firmware Engineer · SharkNinja · Needham, MA
- Principal Mobile Application Developer · SharkNinja · Needham, MA
- Software Engineer II, HR App Engineering · Chewy · Boston, MA
- Software Engineer I, Full Stack, Promotions · Chewy · Boston, MA
- Sr. Software Engineer (Compute Test, North Reading) · Teradyne · MA
Where Burlington, MA ranks
Where Burlington, MA placed in our monthly rankings, month by month. Each month stays online at its own address.
November 2026
- #7Cities where the biggest share of jobs do not need a four-year degree in New England13% · of 15
- #7Best all-round cities for remote workers in New England52 / 100 · of 11
- #8Best cities for pay after cost of living in New England$140k · of 11
- #8Best cities for pay after cost of living in Massachusetts$140k · of 9
- #8Best all-round cities for AI careers in New England27 / 100 · of 11
- #9Best all-round cities for mid-career professionals in New England46 / 100 · of 11
Rankings about engineering jobs
- Best cities for software and engineering jobs #1 San Francisco (3,412 openings)
- Best cities for engineering pay after cost of living #1 San Mateo ($216k)
- Most requested AI skills in engineering jobs #1 AI tools in daily work (6.1%)
- AI tools named most often in engineering jobs #1 Claude (1.7%)
- Employers with the most engineering jobs #1 Amazon (2,992 roles)
How AI is used in this kind of work
Among software developers, AI is already used for some of the tasks. Measured exposure for software developers: 29% (some).
Share of this job’s tasks that AI is already used for at work, from real usage. It is not a forecast of job loss, and a low number means no use seen yet. Source: Anthropic Economic Index.
Skills this job asks for
Say which you have and which you want to build. We use it to match you to jobs like this one.
About the job
How You’ll Contribute:
The Principal Software Development Engineer will bring with them skills and experience in desktop software design and implementation. Reporting to the Director of Software Development, the Principal Software Development Engineer works side-by-side with software, electrical, mechanical engineers, and scientists to design and create software code within our products to achieve design goals. This position is in a cross functional team that is working to develop future generations of our corneal therapy system. The Principal Software Development Engineer will contribute to product design & development, testing, risk analysis, design for reliability, and design for manufacturability of existing and next generation products. The Principal Software Development Engineer will work with Clinical and Regulatory Affairs, Operations, Quality and Marketing/Sales; meeting performance, quality, and cost goals, while optimizing time to market.
What You’ll Do:
Create, with the senior engineering team, the software architecture, design philosophy, design requirements and specifications.
Responsible for all levels of software design and implementation, from algorithm design to coding as well as the necessary design documentation.
Implement software development and design control requirements for regulated markets per 21 CFR 820, IEC 14971, IEC 62304, and applicable FDA guidance.
Responsible for unit testing, and integration testing of software modules. Applies best practices with regards to the use of version control software.
Work closely with the SWQA team to investigate and resolve issues identified during testing.
Work together with hardware designers in order to obtain optimum system performance.
Support maintenance and improvement of legacy products as required
How You’ll Get There:
12+ years of relevant experience.
10+ years of experience in software engineering, algorithm creation, I/O control, systems control, and similar or related activities.
5+ years of progressive and hands-on experience designing and developing commercial software in C#.
5+ years of progressive and hands-on experience designing and developing commercial software using a cross-platform GUI framework such as QT.
Experience with software architecture formulation and assessment, and software technology selection for new products.
Strong working knowledge of common programming languages, especially C, C++, C#, and associated development environments. Python and other high-level language experience are a plus.
Experience with design patterns and experience with architecture patterns like MVC and MVVM is required.
A demonstrated record of innovation and creative problem solving on fast paced engineering projects.
Experience developing applications that incorporate 3rd party libraries and UI components.
Experience with Git.
Experienced at implementing custom command protocols over a variety of communication including TCP/IP.
A record of successful product development – concept through commercialization.
Experienced in writing requirements and specifications.
Strong written and verbal communication skills are essential
Bachelor of Science, Computer Science, Electrical Engineering, Physics, Mathematics, or similar required, Advanced degree preferred
This role works onsite in Burlington, MA
#GKOSUS
Generous. Innovative. Leadership-driven. Family-oriented. Socially responsible.
Founded in 1998, Glaukos Corporation is an ophthalmic pharmaceutical and medical technology company focused on developing and commercializing novel therapies for the treatment of glaucoma, corneal disorders, and retinal diseases.
Our mission at Glaukos is to truly transform vision by pioneering novel, dropless therapies that can meaningfully advance the standard of care and improve the lives of patients suffering from chronic, sight-threatening eye diseases.
Innovation is at the core of everything we do, and we are resolute in our commitment to challenge conventional thinking with new treatment alternatives that are supported by real science, robust clinical evidence, and an unrelenting focus on patients.
Our constant pursuit of game-changing technologies that disrupt legacy treatment paradigms is encapsulated in the Glaukos mantra “We’ll Go First,” which articulates our willingness to take chances, our determination to forge new ground, and our commitment to continuous improvement in all that we do.
Our company completed an initial public offering in June of 2015, and our shares are traded on the New York Stock Exchange under the ticker symbol “GKOS”. Our global headquarters is in Aliso Viejo, California with additional locations in San Clemente, California, and Burlington, Massachusetts.
Glaukos Corporation is an Equal Opportunity/Affirmative Action Employer . All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected Veteran Status, or any other characteristic protected by applicable federal, state, or local law.
All offers of employment are contingent upon the successful completion of a background check, including successfully passing a drug screen, based on the position and local regulations.