Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit https://www.stoketherapeutics.com/

Position Purpose:

The Senior Manager/Associate Director, Legal Operations will be responsible for supporting the execution and continuous improvement of Stoke’s Legal & Compliance Department, including managing the day-to-day infrastructure and operations of the Legal & Compliance Department and driving operational excellence through process improvement, reporting, training, and departmental support initiatives. This position will report into the VP, Corporate Legal.

Key Responsibilities:

Partner closely with the Legal & Compliance team and cross-functional stakeholders, including Finance and IT, to ensure legal and compliance initiatives are effectively implemented and aligned with business objectives

Manage Legal & Compliance department-wide budgeting and financial analysis, including outside counsel budgeting, accrual and forecasting

Develop, implement, and maintain departmental processes, procedures, and workflows

Support and maintain the Legal & Compliance teams IT solutions and AI initiatives and proactively identify new tools for department use

Identify, implement and oversee opportunities for process improvement and operational efficiencies and drive continuous improvement initiatives

Create metrics/trends on KPIs to track effectiveness and efficiency

This role will be expected to take on additional assignments and responsibilities as may be needed to support the Legal & Compliance team and broader business objectives. Responsibilities may change, expand, or shift over time based on organizational priorities, business growth, process improvements, technology implementations, and evolving legal or regulatory requirements

Required Skills & Experience:

Bachelor’s degree required

5+ years of legal operations, legal administration, legal project management, or corporate legal department experience

Pharmaceutical, biotechnology, medical device, or life sciences experience

Effective written and verbal communication skills and interpersonal skills

Strong project management and organizational skills

Detail oriented with excellent analytical and critical thinking abilities

Experience supporting in-house legal departments and with outside counsel management

Experience with contract management, e-billing and AI platforms (ideally including Brightflag and Agiloft)

Experience working cross-functionally in a fast-paced corporate environment

Solutions-oriented problem-solving skills and sound data driven decision-making ability

Location(s):

Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026. This is a hybrid position (2-3 days in office) currently based in Bedford and will later be based in Waltham.

Compensation & Benefits:

At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.

The anticipated salary range for this role at the Senior Manager level is $163,000 - $196,000 and at the Associate Director level is $180,000 - $214,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.

Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.

Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center:

https://www.stoketherapeutics.com/careers/

For more information, visit https://www.stoketherapeutics.com/.

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.