Head Of/Director, Hardware Engineering

Prolific Machines is ushering in a new era of biotechnology with light. Our first-of-its-kind optogenetic platform delivers unprecedented control, precisely guiding cellular behavior when and where it matters most. Unlike existing tools used to control biology, our technology enables dynamic, tunable control over virtually any cellular function in any cell type. We're enabling partners to unlock robust efficiency, quality, and reproducibility advantages across the most complex pharmaceuticals and therapeutic proteins. Prolific is supported by leading investors, including Bill Gates’s Breakthrough Energy Ventures, Mayfield and SOSV.

We're looking for a senior hardware leader to own the hardware engineering function at Prolific: the team that designs and builds our illumination systems, the hardware that delivers light to cells from the bench to bioreactor scale. Reporting to our Co-Founder and CTO, you will lead the transition from validated prototypes to robust, customer-grade products. You'll be the voice of hardware in company planning and be a key partner to the CTO in shaping Prolific's technical direction.

This is not a blank-slate role. You will inherit an exceptional, multidisciplinary team spanning mechatronics, optical, electrical, and firmware engineering that has already designed, built, and shipped illuminators into our own biology and bioprocess labs. They are highly skilled for their level of seniority, and the team has a culture we are genuinely proud of: collaborative, candid, and committed to doing excellent work.

One discipline the team doesn't yet have is systems engineering, and we'd love you to bring it. That means architecting how our systems fit together: modular subsystems, clean interfaces, testable units, and components that are reused where it makes sense, all without over-engineering from the start. A systems engineering background is not strictly required, but a strong systems-level approach to hardware is central to this role.

At Prolific, hardware is an enabler rather than the product itself, working with partners over long trajectories. That makes it essential to be careful where rigor matters, and knowing the difference.

As of today, Prolific is R&D-first: most of our hardware runs in our own labs and in early partner programs, not yet in large deployed fleets. But the timeline to customer-facing hardware is ambitious. The right person is energized by an R&D environment now and has done the R&D-to-product transition before, so they can lead the team through it rather than learn it along the way.

You don't need to be a biologist. Our scientists and bioprocess engineers work side by side with the hardware team, and you'll have deep biology expertise around you from day one. What we need from you is hardware leadership, strong communication and great curiosity.

In your first 6 to 12 months, you will:

Get to know the team and take over day-to-day leadership in a way that preserves what already works well, while setting a clear operating rhythm for planning, design reviews, and delivery

Own the roadmap for our next-generation illuminator platform, including oversight of external development partners

Define the path to GMP readiness for systems used in partner manufacturing environments

Set strong standards for documentation, communication and other good engineering practices

Shape the team's growth: identify the gaps, write the hiring plan, and make the first hires

Hardware operations and project management have dedicated owners on the team. You'll work closely with them, but you won't be running the shop by yourself.

This role is based on-site in Emeryville, CA, with the flexibility to work remotely on occasion.

Responsibilities:

Strategy and functional leadership

Translate company strategy into a multi-year hardware strategy and roadmap, and turn it into concrete functional plans, milestones, and success measures

Partner with the CTO to define Prolific's technical roadmap, engineering standards, and decision-making frameworks

Contribute to company business planning as the hardware function's representative, including budgets, headcount, capital equipment, and partner program commitments

Make most operational and technical decisions for the hardware function independently, escalating where strategic alignment is needed

Build strong partnerships with peer leaders in bioprocess engineering, biology, software, data, and business development so hardware plans integrate with company-wide priorities

Represent Prolific externally with partners, suppliers, and the broader engineering community, and bring outside expertise and industry connections into the company

Model commitment to company decisions, aligning the hardware team behind agreed outcomes even when they differ from your own recommendation

Leadership and team development

Conserve and strengthen the hardware team's culture of collaboration, candor, and craftsmanship as the team grows

Lead, mentor, and develop a strong multidisciplinary team, elevating already capable engineers to the next level and growing senior individual contributors into technical and people leads

Coach the team in balancing speed and rigor: when to prototype quickly, when to slow down and do it properly, and how to make that call with confidence

Own the structure and operations of the hardware function: team design, roles, resourcing, and a predictable operating rhythm (planning, design reviews, retrospectives) that adds clarity without adding bureaucracy

Own hardware team growth: identify capability gaps (e.g. systems, testing, quality), write the hiring plan, and hire people who strengthen the culture

Manage up and down effectively, communicating clearly about tradeoffs in scope, quality, time, and people

Hardware development

Bring a systems engineering approach to the platform: define subsystem boundaries and interfaces, requirements flow-down, and modular designs that enable rapid scaling, independent testing, and component reuse, without over-engineering early

Take on the hardest, least precedented technical problems in scaling light delivery to industrial bioprocessing, and develop solutions that hold up long term

Oversee the full development lifecycle, from technical scoping and concept through prototyping, verification and validation, and transfer to production

Lead the transition from R&D prototypes to reliable, serviceable, manufacturable products (design for manufacturing, design for service, design controls)

Drive make-vs-buy and insource-vs-outsource decisions, and manage external development partners and contract manufacturers against clear scopes and milestones

Support business development with technical scoping and realistic estimates for partner programs

Quality, compliance, and productization

Define and execute the path to GMP readiness for hardware used in partner manufacturing environments

Lead electrical safety and regulatory certification efforts with test labs and consultants

Establish the right-sized quality practices for each stage: documentation, change control, verification records, and supplier qualification

Work with hardware operations to make sure what the team designs can be built, deployed, and supported at scale

Requirements:

BS, MS, or PhD in Mechanical, Electrical, Optical, Systems, or Biomedical Engineering, or a related field; equivalent experience considered

10+ years of relevant industry experience, including