Sr. Associate Scientist I / II – High Throughput Chemistry

JOB SUMMARY

We are seeking a motivated and detail-oriented Sr. Associate Scientist to join our Discovery Chemistry team at Iambic Therapeutics in San Diego, CA. In this role, the successful candidate will apply hands-on synthetic chemistry skills to execute high-throughput experiments and support compound library campaigns. Candidates will be leveled based on experience, technical depth, and demonstrated independence. The successful candidate will work cross-functionally with broader chemistry, biology, compound management, AI/ML, and software teams across the discovery pipeline, leveraging Iambic's HTE platform to accelerate our programs. This position will be based in our San Diego Headquarters.

KEY RESPONSIBILITIES

• Execute parallel synthetic chemistry experiments in support of compound library campaigns.

• Execute and refine standard company procedures and synthetic methods to ensure high success rate and project impact.

• Operate, maintain, and calibrate laboratory automation and analytical/purification equipment used in the HTE workflow.

• Collaborate with senior chemists and cross-functional partners to adapt bench-scale synthetic routes to automation-compatible, high-throughput processes.

• Record, organize, and analyze experimental and library compound data; communicate results clearly to project teams.

• Ensure all laboratory work follows established safety protocols and best practices for ELN data recording.

• Identify bottlenecks in existing processes and contribute to solutions that ensure business continuity.

QUALIFICATIONS

Required:

• MS degree in Organic Chemistry with 3+ years of experience or BS in Organic Chemistry with 5+ years of industry experience.

• Strong foundation in modern organic synthetic methods.

• Direct experience with High Throughput Chemistry and/or Parallel Synthesis.

• Familiarity with laboratory automation, liquid handling robotics, and automated analytical/purification systems, and high adaptability to existing technology.

• Ability to thrive in a fast-paced, highly collaborative, and dynamic research environment.

• Strong written and verbal communication skills; able to clearly convey technical results to colleagues and cross-functional partners.

Strongly Preferred:

• Prior hands-on experience with Direct-to-Biology (D2B) strategies for drug discovery.

• Familiarity with the principles of medicinal chemistry.

ABOUT IAMBIC THERAPEUTICS Iambic Therapeutics (Nasdaq: IAM) is a technology and clinical-stage life sciences company headquartered in San Diego. By utilizing molecular superintelligence — integrating proprietary AI with automated, scalable chemistry and biology experimentation — our platform is designed to address the totality of drug discovery and development. At Iambic, we are building an engine that is designed to power the future of medicine. Learn more at iambic.ai.

MISSION & VALUES Our mission is to make better technology for better medicines. Three values guide how we work:

• Bold. We are courageous, take thoughtful risks, and approach challenges with tenacity.

• Innovative. We are creative and find new solutions that deliver impact.

• Collaborative. We respect one another and partner with integrity.

We value the range of perspectives our people bring, and we work to build an environment where every team member can contribute and grow.

PAY AND BENEFITS The pay range for this role is listed above. Actual pay depends on factors including experience, skills, and location. Eligible employees in the U.S. receive company-paid medical coverage, flexible spending accounts, voluntary life insurance, 401(k) matching and flexible time off. We are in a brand-new state-of-the art facility in beautiful San Diego with a community gym, dining, and easy access to great places to live and play.

EQUAL OPPORTUNITY Iambic is an equal opportunity employer. We consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity or expression, national origin, ancestry, age, disability, medical condition, genetic information, marital status, veteran or military status, or any other characteristic protected by law.